Circadian Rhythms – what they are and how they support weight and health


All over Instagram they are talking about circadian rhythms. I decided to do some research and find out a little bit more about the relevance and the role of circadian rhythms in health and health care.

Circadian rhythm is the natural, internal process that regulates the sleep-wake cycle and repeats roughly every 24 hours. It is driven by a biological clock located in the brain and is influenced by environmental cues such as light and temperature. Here’s a closer look at how circadian rhythms work, their significance, and factors that can affect them:

How Circadian Rhythms Work

  1. Biological Clock:
    • The primary biological clock that controls circadian rhythms is located in the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain.
    • The SCN receives direct input from the eyes, specifically detecting changes in light.
  2. Light and Darkness:
    • Light is the most significant external cue (zeitgeber) that influences circadian rhythms. Exposure to light signals the SCN to suppress the production of melatonin, a hormone that promotes sleep.
    • In contrast, darkness triggers the SCN to signal the pineal gland to produce melatonin, making you feel sleepy.
  3. Hormonal Regulation:
    • Melatonin and cortisol are key hormones regulated by circadian rhythms. Melatonin levels rise in the evening, promoting sleep, and fall in the morning. Cortisol, which helps wake you up, peaks in the early morning.
  4. Body Temperature:
    • Body temperature also follows a circadian pattern, typically decreasing at night to facilitate sleep and rising in the morning to promote wakefulness.

Significance of Circadian Rhythms

  1. Sleep-Wake Cycle:
    • The most well-known function of circadian rhythms is regulating the sleep-wake cycle, helping to ensure a consistent and restful sleep pattern.
  2. Hormone Production:
    • Circadian rhythms influence the production and release of various hormones, affecting metabolism, immune function, and other bodily processes.
  3. Mental Health:
    • Disruptions in circadian rhythms are associated with various mental health disorders, including depression, anxiety, and bipolar disorder.
  4. Physical Health:
    • Proper circadian rhythm function is crucial for cardiovascular health, digestion, and overall physical well-being.

Factors Affecting Circadian Rhythms

  1. Light Exposure:
    • Artificial light, especially blue light from screens, can disrupt circadian rhythms by inhibiting melatonin production.
    • Lack of natural light during the day can also affect the alignment of your circadian rhythm.
  2. Shift Work:
    • Working irregular hours, particularly night shifts, can lead to a misalignment of your circadian rhythm, causing sleep disorders and other health issues.
  3. Travel:
    • Crossing time zones rapidly, such as during air travel, can result in jet lag, a temporary disruption of circadian rhythms.
  4. Lifestyle Factors:
    • Irregular sleep patterns, poor diet, and lack of physical activity can negatively impact circadian rhythms.
  5. Age:
    • Circadian rhythms can change with age. For example, teenagers often have a delayed sleep phase, making them prefer later bedtimes and wake-up times.

Maintaining Healthy Circadian Rhythms

  1. Consistent Sleep Schedule:
    • Going to bed and waking up at the same time every day helps reinforce your circadian rhythms.
  2. Light Management:
    • Get plenty of natural light during the day and reduce exposure to artificial light, especially blue light from screens, in the evening.
  3. Healthy Lifestyle:
    • Regular physical activity, a balanced diet, and good hydration support overall health and stable circadian rhythms.
  4. Sleep Environment:
    • Create a sleep-conducive environment that is dark, cool, and quiet to promote better sleep quality. That means keeping screens (phone, laptop and TV) out of the bedroom.

As you can see from this article circadian rhythms are fundamental to our health and well-being, governing many of our bodily functions. Understanding and maintaining them can help improve sleep, boost mood, and enhance overall health.

References

  1. Reppert, S. M., & Weaver, D. R. (2002). Coordination of circadian timing in mammals. Nature, 418(6901), 935-941.
  2. Saper, C. B., Scammell, T. E., & Lu, J. (2005). Hypothalamic regulation of sleep and circadian rhythms. Nature, 437(7063), 1257-1263.
  3. Cajochen, C., Zeitzer, J. M., Czeisler, C. A., & Dijk, D. J. (2000). Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behavioural Brain Research, 115(1), 75-83.
  4. Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190-3199.
  5. Arendt, J. (2005). Melatonin: characteristics, concerns, and prospects. Journal of Biological Rhythms, 20(4), 291-303.
  6. Krauchi, K., & Wirz-Justice, A. (1994). Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 267(3), R819-R829.
  7. Carskadon, M. A., & Dement, W. C. (2005). Normal human sleep: an overview. Principles and Practice of Sleep Medicine, 4, 13-23.
  8. Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003). A clockwork web: circadian timing in brain and periphery, in health and disease. Nature Reviews Neuroscience, 4(8), 649-661.
  9. Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010). Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nature Reviews Neuroscience, 11(8), 589-599.
  10. Scheer, F. A., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proceedings of the National Academy of Sciences, 106(11), 4453-4458.
  11. Chang, A. M., Aeschbach, D., Duffy, J. F., & Czeisler, C. A. (2015). Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proceedings of the National Academy of Sciences, 112(4), 1232-1237.
  12. Boivin, D. B., & Boudreau, P. (2014). Impacts of shift work on sleep and circadian rhythms. Pathologie Biologie, 62(5), 292-301.
  13. Kecklund, G., & Axelsson, J. (2016). Health consequences of shift work and insufficient sleep. BMJ, 355, i5210.
  14. Eastman, C. I., & Burgess, H. J. (2009). How to travel the world without jet lag. Sleep Medicine Clinics, 4(2), 241-255.
  15. Buxton, O. M., & Marcelli, E. (2010). Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States. Social Science & Medicine, 71(5), 1027-1036.
  16. Crowley, S. J., Acebo, C., & Carskadon, M. A. (2007). Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Medicine, 8(6), 602-612.
  17. Hirshkowitz, M., Whiton, K., Albert, S. M., Alessi, C., Bruni, O., DonCarlos, L., ... & Adams Hillard, P. J. (2015). National Sleep Foundation’s updated sleep duration recommendations: final report. Sleep Health, 1(4), 233-243.
  18. Wright, K. P., McHill, A. W., Birks, B. R., Griffin, B. R., Rusterholz, T., & Chinoy, E. D. (2013). Entrainment of the human circadian clock to the natural light-dark cycle. Current Biology, 23(16), 1554-1558.
  19. **Van Cauter, E., & Knutson, K. L. (2008). Sleep and the epidemic of obesity in children and adults. *European Journal of Endocrinology,
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